The Li Lab and our collaborators from across the McMaster community have published our first report on our novel aptamers for COVID19! The lab has refocused our efforts over the past year to address pressing COVID19 problems and we’re excited to finally be sharing our work. Read more about our work at Pubmed.
Tag: Publication Highlights
Descriptions of (recently) published scientific articles.
A DNAzyme Feedback Amplification Strategy for Biosensing
Take a look at this recent publication from the Li Lab in Angewandte Chemie International Edition. In this paper, we explore a novel signal amplification strategy termed DNAzyme feedback amplification (DFA). This method takes advantage of rolling circle amplification and RNA-cleaving DNAzymes for biosensing applications, with sensitivity improvements of 3-6 orders of magnitude when compared to conventional methods. -Suraj
Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test
Checkout this recent paper from the Li Lab in Scientific Reports, “Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test.” Here we report on a novel DNA detection method that combines the advantages of the polymerase chain reaction with the simplicity of a litmus test. The diagnostic capabilities of the platform is demonstrated using clinically validated stool samples from C.difficile infected patients. -Suraj
Programming a topologically constrained DNA nanostructure into a sensor
Checkout the Li Lab’s latest paper in Nature Communications! In a collaborative project between the Li Lab and McMaster’s Biointerfaces Institute, we report a novel reporter system based on mechanically interlocked circular DNA, rolling circle amplification and DNAzymes for highly sensitive bacterial detection.
C.difficile Detection
Read about a new highly specific Clostridium difficile catalytic DNA biosensor in the Li Lab’s latest publication in Angewandte Chemie International Edition. You can also checkout the a profile of the report on the McMaster Daily News.
Turning up the Volume on Target Detection
Check out the Li Lab’s latest publication in Angewandte Chemie International Edition, “Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly”. Postdoc Meng Liu has developed a novel, high sensitivity DNA based signal amplification technique using an isothermal DNA polymerase and structure switching DNA aptamers. This work brings DNA aptamer based detection technologies another step closer to convenient and cost effective point of care applications.
-Jim
Translating Bacterial Detection by DNAzymes into a Litmus Test
Last week, our publication entitled “Translating Bacterial Detection by DNAzymes into a Litmus Test” was published in Angewante Chemie. The article was well received and was featured on several social media outlets. We were also excited to be featured on the back cover of the journal in which our very own Qian Feng conceptualized the artwork. Since then, we have put together a fantastic team to move this technology forward and to open up new avenues of research. It has been a very satisfying process to see two years of our hard work receive so much attention and we are excited to see how this technology will continue to grow!
-Kha