Zijie Zhang

Postdoctoral Fellow

Ph.D. Chemistry, University of Waterloo, 2019

M.Sc. Biochemistry, Beijing University of Chemical Technology, 2015

Department of Biochemistry and Biomedical Sciences
McMaster University
HSC Room 4H32
1280 Main Street West
Hamilton, Ontario, L8S 4K1

Tel. 905.525.9140 ext.28813
Tel. 905.522.9033
Mail. zhanz330@mcmaster.ca


Brief Biography

Zijie obtained his Ph.D of Chemistry in the University of Waterloo in 2019 and then began his postdoc work in the Li lab. His research focuses on DNA aptamers for pathogen diagnostics.

Research Interests

Functional nucleic acids; Aptamer selections; Pathogen diagnostics; Nanomaterials.


1. Zijie Zhang, Payel Sen, Bal Ram Adhikari, Yingfu Li*, Leyla Soleymani*. “Development of Nucleic Acid‐based Electrochemical Biosensors for Clinical Applications”, Angewandte Chemie 2022, https://doi.org/10.1002/anie.202212496

2.  Amanda Victorious, Zijie Zhang, Dingran Chang, Jimmy Gu, Todd Hoare, Leyla Soleymani*, Yingfu Li*. “Inside Back Cover: A DNA Barcode‐Based Aptasensor Enables Rapid Testing of Porcine Epidemic Diarrhea Viruses in Swine Saliva Using Electrochemical Readout”, Angewandte Chemie 2022, 134, e202204252.

3.  Zijie Zhang, Jiuxing Li, Jimmy Gu, Ryan Amini, Leyla Soleymani, John D. Brennan*, Yingfu Li*, “Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS-CoV-2 Variants of Concern”, Chemistry–A European Journal 2022, 28, e202200078.

4.  Zijie Zhang, Richa Pandey, Jiuxing Li, Jimmy Gu, Dawn White, John D. Brennan*, Yingfu Li*, “High Affinity Dimeric Aptamers Enable Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva”, Angewandte Chemie International Edition 2021, 60, 24266-24274.

5.  Jiuxing Li, Zijie Zhang, Jimmy Gu, Hannah D. Stacey, Jann C. Ang, John D. Brennan*, Yingfu Li*. “Diverse High-affinity DNA Aptamers for Wild-type and B.1.1.7 SARS-CoV-2 Spike Proteins from a Pre-structured DNA Library”, Nucleic Acids Research 2021, 49, 7267-7279.

6.  Amini, Ryan, Zijie Zhang, Jiuxing Li, Jimmy Gu, John D. Brennan, Yingfu Li*. “Aptamers for SARS‐CoV‐2: Isolation, Characterization, and Diagnostic and Therapeutic Developments.” Analysis & Sensing 2022, 2, e202200012.

7. Zijie Zhang and Juewen Liu*, “Intracellular Delivery of a Molecularly Imprinted Peroxidase Mimicking DNAzyme for Selective Oxidation”, Materials Horizons 2018, 5, 738-744.

8. Zijie Zhang, Kiyoshi Morishita, Wei Ting David Lin, Po-Jung Jimmy Huang and Juewen Liu*, “Nucleotide Coordination with 14 Lanthanides Studied by Isothermal Titration Calorimetry”, Chinese Chemical Letters 2018, 29, 151-156.

9. Zijie Zhang and Juewen Liu*, “An Engineered One-site Aptamer with Higher Sensitivity for Label-free Detection of Adenosine on Graphene Oxide”, Canadian Journal of Chemistry 2018, 96, 957-963.

10. Zijie Zhang, Olatunji Oni and Juewen Liu*, “New Insights into a Classic Aptamer: Binding Sites, Cooperativity and More Sensitive Adenosine Detection”, Nucleic Acids Research 2017, 45, 7593-7601.

11. Zijie Zhang, Xiaohan Zhang, Biwu Liu and Juewen Liu*, “Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity”, Journal of the American Chemical Society 2017, 139, 5412-5419.