Jiuxing Li

Postdoctoral Fellow

2016-2017 Research Scientist, Chemistry, Michigan Technological University, USA

2011- 2016 Ph.D., Analytical Chemistry, Xiamen University, China

2007- 2011 B.S., Chemistry, Xiamen University, China

Department of Biochemistry and Biomedical Sciences
McMaster University
HSC Room 4H32
1280 Main Street West
Hamilton, Ontario, L8S 4K1

Tel. 905.525.9140 ext.28813
Mail. lij330@mcmaster.ca


Brief Biography

From 2011 to 2016, Jiuxing worked in Prof. Chaoyong Yang’s lab at Xiamen University, China. During that period, his research focused on the synthesis and characterization of noble metal nanoparticles for biosensors. In the next year, he worked as a postdoctoral fellow at Michigan Technological University, USA. Jiuxing joined the Li lab in the fall of 2017. His research interests include selection and application of DNA aptamers for the detection pathogenic bacteria and viruses.

Research Interests

Aptamer selection, development of biosensors with noble metal nanoparticles, virus and bacterial detection


[1] Li, Jiuxing; Yang, Chaoyong* An in situ Pt Staining Method for Simple, Stable, and Sensitive Pressure-based Bioassays; ACS Appl. Mater. Interfaces, 2018, 10, 13390–13396

[2] Li, Jiuxing; Gao, Z.; Ye, H.; Wan, S.; Pierce, M.; Tang, D.; Xia, Xiaohu* A non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers; Chem. Commun. 2017, 53, 9055-9058. (front-cover)

[3] Li, Jiuxing; Zhu, Z.; Zhu, B.; Ma, Y.; Lin, B.; Liu, R.; Song, Y.; Lin, H.; Tu, S.; Yang, Chaoyong* Surface-Enhanced Raman Scattering Active Plasmonic Nanoparticles with Ultrasmall Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging; Anal. Chem. 2016, 88, 7828-7836.

[4] Li, Jiuxing; Zhu, Z.; Liu, F.; Zhu, B.; Ma, Y.; Yan, J.; Lin, B.; Ke, G.; Liu, R.; Zhou, L.; Tu, S.; Yang, Chaoyong* DNA-Mediated Morphological Control of Silver Nanoparticles; Small 2016, 12, 5449-5487.

[5] Li, Jiuxing; Zhu, B.; Zhu, Z.; Zhang, Y.; Yao, X.; Tu, S.; Liu, R.; Jia, S.; Yang, Chaoyong* Simple and Rapid Functionalization of Gold Nanorods with Oligonucleotides Using an mPEG-SH/Tween 20-Assisted Approach; Langmuir 2015, 31, 7869-7876.

[6] Li, Jiuxing; Liu, R.; Zhang, Y.; Zhu, B.; Yao, X.; Lin, H.; Zhou, L.; Zhu, Z.; Yang, Chaoyong* Application of DNA functionalized gold nanoparticles; Scientia Sinica Chimica: Chemistry 2015, 45, 1112-1144.

[7] Li, Jiuxing; Zhu, B.; Yao, X.; Zhang, Y.; Zhu, Z.; Tu, S.; Jia, S.; Liu, R.; Kang, H.; Yang, Chaoyong J. Synergetic Approach for Simple and Rapid Conjugation of Gold Nanoparticles with Oligonucleotides; ACS Appl. Mater. Interfaces 2014, 6, 16800-16807.

[8]    Jiuxing Li, Shadman Khan, Jimmy Gu, Carlos D. M. Filipe*, Tohid F. Didar*, Yingfu Li*. A simple Au-on-Au colorimetric sensor for food-borne pathogen Salmonella typhimurium. Angew. Chem. Int. Ed. 2023, e202300828. (DOI: 10.1002/anie.202300828, IF: 16.8)

[9]    Jiuxing Li, Zijie Zhang, Jimmy Gu, Ryan Amini, Alexandria Mansfield, Jianrun Xia, Dawn White, Hannah D. Stacey, Jann C. Ang, Gurpreet Panesar, Alfredo Capretta, Carlos D. M. Filipe, Karen Mossman, Bruno J. Salena, Jonathan Gubbay, Cynthia Balion, Leyla Soleymani, Matthew S. Miller, Deborah Yamamura, John D. Brennan*, and Yingfu Li*. Three on three: Universal and high-affinity molecular recognition of the symmetric homotrimeric spike protein of SARS-CoV-2 with a symmetric homotrimeric aptamer. J. Am. Chem. Soc. 2022, 144, 23465–23473. (DOI: 10.1021/jacs.2c09870, IF: 16.38)

[10]    Jiuxing Li§; Zhang, Z.§; Gu, J.; Stacey, H. D.; Ang, J. C.; Miller, M. S.; Capretta, A.; Mossman, K. L.; Yamamura, D.; Brennan, J. D.; Yingfu Li*. Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library. Nucleic Acids Res. 2021, 49, 7267–7279. (SCI: 000685211300011, IF: 19.2)

[11]    (Joint first authors) Zhang, Z.§; Pandey, R.§; Jiuxing Li§, Gu, J.; White, D.; Stacey, H. D.; Ang, J. C.; Steinberg, C.-J.; Capretta, A.; Filipe, C. D. M.; Soleymani, L.*; Brennan J. D.*; and Yingfu Li*. High affinity dimeric aptamers enable rapid electrochemical detection of Wild-Type and B.1.1.7 SARS-CoV-2 in unprocessed saliva. Angew. Chem. Int. Ed. 2021, 60, 24266–24274. (SCI: 000703116700001, IF: 16.8)

[12]    (Joint first authors) Zhang, Z. §; Jiuxing Li§; Amini, R.; Mansfield, A.; Gu, J.; Xia, J.; Brennan, J.; Yingfu Li*, Comparative Characterization of Diverse DNA Aptamers for Recognition of Spike Proteins of Multiple SARS-CoV-2 Variants. Anal. Sens. 2023, e202300001. (DOI: doi.org/10.1002/anse.202300001)

[13]    Jiuxing Li§, Zijie Zhang§, Rudi Liu§, Ryan Amini, Bruno J. Salena, and Yingfu Li*. Discovery and translation of functional nucleic acids for clinically diagnosing infectious diseases: opportunities and challenges. TrAC, Trends Anal. Chem. 2023, 158, 116886 (DOI: 10.1016/j.trac.2022.116886, IF: 12.296)

[14]    (Joint first authors) Zhang, Z.§; Jiuxing Li§, Gu, J.; Amini, R.; Stacey, H. D.; Ang, J. C.; White, D.; Filipe, C. D. M.; Mossman, K.; Miller, M. S., Brennan J. D.*; and Yingfu Li*. A universal DNA aptamer that recognizes spike proteins of diverse SARS-CoV-2 variants of concern. Chem. Eur. J. 2022, 28, e202200078. (Front cover article, Cover Feature article, ChemistryViews report, SCI: 000757547300001, IF: 5.0)