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Simon McManus

Graduate Student

Ph.D. Biochemistry, McMaster University, anticipated 2011

B.Sc. (Honours) Molecular Biology, McMaster University/Lancaster University, 2003

Department of Biochemistry and Biomedical Sciences
McMaster University
Health Science Centre, Room 4H31B
1280 Main Street West
Hamilton, Ontario, L8S 4K1

905.525.9140 ext.22757 | ext.28813
905.522.9033
mcmanusa@mcmaster.ca

Brief Biography:

Simon completed his H. BSc. in molecular biology at McMaster University in 2003. During his undergraduate studies, he spent a year studying at Lancaster University located in Lancashire, U.K. Upon returning to Canada, he joined the Li Lab and started his graduate studies in September, 2003. In addition to pursuing his doctoral degree, he has also worked as a research scientist for a local biotechnology company, developing novel nucleic acid-based biosensors.

Apart from deoxyribozymes and guanine quadruplexes, Simon is also a huge fan of hockey, hiking, and Homer Simpson.

"If I could be anyone for one day, living or dead, real or fictional, I would be…Dr. Who"

Research Interests:

My research interest and experience are primarily in the areas of functional nucleic acids, structural and functional characterization of deoxyribozymes and in vitro selection.

Awards:

  • Colin James Lyne Lock Scholarship (Ontario Graduate Scholarships), 2008-2009
  • David L. Prosser Scholarship (Ontario Graduate Scholarships in Science and Technology), 2006-2007
  • Poster Competition Finalist, 2009 Riboclub Opening Session, September 2009
  • Nucleic Acids Poster Award, 92nd Canadian Chemistry Conference (Canadian Society for Chemistry), June 2009
  • Outstanding Poster Presentation Award, 87th Canadian Chemistry Conference (CSC), June 2004

Publications:


Journal Articles:
5.
McManus, S. A. and Li, Y. The Structural Diversity of Deoxyribozymes. (2010). Molecules 15, 6269-6284. [link]
4.
McManus, S. A. and Li, Y. A Deoxyribozyme with a Novel Quartet/Helix Pseudoknot Structure. (2008). Journal of Molecular Biology 375, 960-968. [link]
3.
Zhao, W., Chiuman, W., Lam, J., McManus, S. A., Chen, W., Cui, Y., Pelton, R., Brook, M. A. and Li, Y. DNA Aptamer Folding on Gold Nanoparticles: From Colloid Chemistry to Biosensors. (2008). Journal of the American Chemical Society 130, 3610-3618. [link]
2.
McManus, S. A. and Li, Y. Multiple Occurrences of an Efficient Self-phosphorylating DNA motif. (2007). Biochemistry 46, 2198-2204. [link]
1.
Achenbach, J. C., Jeffries, G. A, McManus, S. A., Billen, L. P. and Li, Y. Secondary-Structure Characterization of Two Proficient Kinase Deoxyribozymes. (2005). Biochemistry 44, 3765-3774 [link]
Book Chapters:
1.
Schlosser, K., McManus, S. A. and Li, Y. Deoxyribozymes: Catalytically Active DNA Molecules. (2005). In The Aptamer Handbook. Wiley Press.
Copyright © 2011 Yingfu Li Lab, Department of Biochemistry, McMaster University. All Rights Reserved.