A DNAzyme Feedback Amplification Strategy for Biosensing

Take a look at this recent publication from the Li Lab in Angewandte Chemie International Edition. In this paper, we explore a novel signal amplification strategy termed DNAzyme feedback amplification (DFA). This method takes advantage of rolling circle amplification and RNA-cleaving DNAzymes for biosensing applications, with sensitivity improvements of 3-6 orders of magnitude when compared to conventional methods. -Suraj

Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test

Checkout this recent paper from the Li Lab in Scientific Reports, “Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test.” Here we report on a novel DNA detection method that combines the advantages of the polymerase chain reaction with the simplicity of a litmus test. The diagnostic capabilities of the platform is demonstrated using clinically validated stool samples from C.difficile infected patients. -Suraj

 

 

Funding for Legionella Biosensors Brings Research and Industry Together

Funding was recently announced to advance the Li lab’s research into rapid Legionella diagnostic technologies. Congratulations to our McMaster collaborators Dr. Carlos Filipe and Dr. John Brennan of the Biointerfaces Institute  and industry partners TGWT Clean Technologies Inc., Cytodiagnostics and Mold and Bacterial Consulting Labs. Read more about it on the McMaster News website.

A Busy Week of Holiday Festivities

The Li Lab came together to participate in the departmental ginger bread house contest, coming up with a 2 part winter wonderland gingerbread house and Eiffel tower. Congrats to us on winning 1st place! Check out the rest of the details at the BBS Facebook Page.

Christmas 2015 3

Christmas 2015 2

Everyone also came out to the annual Li Lab Christmas lunch.

Christmas 2015

Finally, our 2nd annual Secret Santa was also a huge success and a lot of fun!

Turning up the Volume on Target Detection

menglCheck out the Li Lab’s latest publication in Angewandte Chemie International Edition“Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly”. Postdoc Meng Liu has developed a novel, high sensitivity DNA based signal amplification technique using an isothermal DNA polymerase and structure switching DNA aptamers. This work brings DNA aptamer based detection technologies another step closer to convenient and cost effective point of care applications.

-Jim