Congratulations to the Andres and Li Labs for a team effort in creating this Magic School Bus costume. The bus was driven to first place by Dr. Li as Ms. Frizzle and Dr. Andres as “Liz” the chameleon.
Take a look at this recent publication from the Li Lab in Angewandte Chemie International Edition. In this paper, we explore a novel signal amplification strategy termed DNAzyme feedback amplification (DFA). This method takes advantage of rolling circle amplification and RNA-cleaving DNAzymes for biosensing applications, with sensitivity improvements of 3-6 orders of magnitude when compared to conventional methods. -Suraj
Checkout this recent paper from the Li Lab in Scientific Reports, “Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test.” Here we report on a novel DNA detection method that combines the advantages of the polymerase chain reaction with the simplicity of a litmus test. The diagnostic capabilities of the platform is demonstrated using clinically validated stool samples from C.difficile infected patients. -Suraj
Yingfu as the “Crazy Cat Lady” and his gang of cats
Funding was recently announced to advance the Li lab’s research into rapid Legionella diagnostic technologies. Congratulations to our McMaster collaborators Dr. Carlos Filipe and Dr. John Brennan of the Biointerfaces Institute and industry partners TGWT Clean Technologies Inc., Cytodiagnostics and Mold and Bacterial Consulting Labs. Read more about it on the McMaster News website.
Checkout the Li Lab’s latest paper in Nature Communications! In a collaborative project between the Li Lab and McMaster’s Biointerfaces Institute, we report a novel reporter system based on mechanically interlocked circular DNA, rolling circle amplification and DNAzymes for highly sensitive bacterial detection.
The Li Lab came together to participate in the departmental ginger bread house contest, coming up with a 2 part winter wonderland gingerbread house and Eiffel tower. Congrats to us on winning 1st place! Check out the rest of the details at the BBS Facebook Page.
Everyone also came out to the annual Li Lab Christmas lunch.
Finally, our 2nd annual Secret Santa was also a huge success and a lot of fun!
The Li Lab celebrated another Halloween with the Department of Biochemistry and Biomedical Sciences by participating in the annual costume contest. Graduate and undergraduate students united to put together a winning Cowboy Rollercoaster themed group costume. Visit the BBS Facebook Page to see all the other great costumes.
Check out the Li Lab’s latest publication in Angewandte Chemie International Edition, “Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly”. Postdoc Meng Liu has developed a novel, high sensitivity DNA based signal amplification technique using an isothermal DNA polymerase and structure switching DNA aptamers. This work brings DNA aptamer based detection technologies another step closer to convenient and cost effective point of care applications.